가토 상악동 거상술 후 Bovine Bone (Bio-Oss®)과 함께 이식된 혈소판풍부혈장과 혈소판결핍혈장의 골치유능 비교
Effect of bovine bone (Bio-Oss®) and platelet rich plasma, platelet poor plasma on sinus bone graft in rabbit
이태형, 정유민, 최용근, 이의석, 장현석, 임재석,
소속 상세정보
이태형 ( Lee Tai-Hyung ) - 고려대학교 의과대학 구강악안면외과학교실
정유민 ( Jeong You-Min ) - 고려대학교 의과대학 구강악안면외과학교실
최용근 ( Choi Yong-Geun ) - EB치과의원
이의석 ( Lee Eui-Seok ) - 고려대학교 의과대학 구강악안면외과학교실
장현석 ( Jang Hyon-Seok ) - 고려대학교 의과대학 구강악안면외과학교실
임재석 ( Rim Jae-Suk ) - 고려대학교 의과대학 구강악안면외과학교실
KMID : 0355620100360010039
Abstract
Maxillary sinus lift and bone graft are used to reconstruct atrophic maxilla molar area for endosseous dental implants. Many different grafting materials and techniques can be used for maxillary sinus bone graft.
Bio-Oss® has been proposed as bone substitute and successfully utilized as osteoconductive filler. Platelet rich plasma (PRP) is an autologous material with many growth factors, such as PDGF, TGF-β, IGF, VEGF, facilitating bone healing process. And Platelet poor plasma (PPP) is the by-product in procedure of producing PRP.
Six rabbits were used as experimental animal. Both maxillary sinus were grafted with Bio-Oss® and PRP, and Bio-Oss® and PPP. Rabbits were sacrificed at 4, 8 and 12 weeks. The grafting sites were evaluated by histomorphometric analysis.
As a result, using PRP showed excellent bone formation in the early stage, but no further significant effect after that. In late stage, the ability of bone formation of using PRP was even worse than using PPP. The further studies need to be considered in this case.
키워드
Maxillary sinus; Bio-Oss®;Platelet-rich plasma (PRP);Platelet poor plasma (PPP)
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